Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus.
نویسندگان
چکیده
Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 μg/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be facilitated by a cryptic mutation or mutations associated with chloramphenicol resistance.
منابع مشابه
Methicillin-resistant Staphylococcus aureus with the MIC of linezolid
35 Methicillin-resistant Staphylococcus aureus with the MIC of linezolid 4 μg/ml, isolated from an 36 unsuccessful linezolid therapy patient, yielded linezolid-resistant mutants in blood agar at 48 h of 37 incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and 38 accumulated the T2500A mutation(s) of the ribosomal RNA genes. Emergence of these resistant clones...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 55 5 شماره
صفحات -
تاریخ انتشار 2011